Human blood metabolite timetable indicates internal body time

RESEARCH ARTICLE

PNAS Proceedings of the National Academy of Sciences of the United States of America

_________________________________________________________________________________________________

Human blood metabolite timetable indicates internal body time

Abstract

A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body time from samples taken at only a few time points. Here we applied this molecular-timetable concept to estimate and evaluate internal body time in humans. We constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency while simultaneously controlling for the confounding effects of activity level, light, temperature, sleep, and food intake. By using this metabolite timetable as a reference, we accurately determined internal body time within 3 h from just two anti-phase blood samples. Our minimally invasive, molecular-timetable method with human blood enables highly optimized and personalized medicine.

_________________________________________________________________________________________________

Read full article (open access) via the source

Pdf version PNAS-2012-Kasukawa-1207768109

_________________________________________________________________________________________________

Takeya Kasukawaa, Masahiro Sugimotob, Akiko Hidad, Yoichi Minamie, Masayo Morib, Sato Honmaf, Ken-ichi Honmaf, Kazuo Mishimad, Tomoyoshi Sogab, & Hiroki R. Uedaa (2012).
Human blood metabolite timetable indicates internal body time

PNAS Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.1207768109

_________________________________________________________________________________________________

Tracing Knowledge Notification | Ειδοποίηση Στα ίχνη της Γνώσης

UNMODIFIED COPY
of the original post, out of respect to the source and readers.
Please follow the link for references and more informations.

ΑΠΑΡΑΛΛΑΚΤΟ ΑΝΤΙΓΡΑΦΟ
της πρωτότυπης δημοσίευσης με σεβασμό στην πηγή και στους αναγνώστες.
Παρακαλώ επισκεφθείτε τον σύνδεσμο για περισσότερες πληροφορίες.

Human blood metabolite timetable indicates internal body time.