Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease

Περιοδοντίτιδα και κίνδυνος Χρόνιας Αποφρακτικής Πνευμονοπάθειας
(χρόνια βρογχίτιδα, εμφύσημα)
Chronic obstructive pulmonary disease (COPD)
επίσης γνωστή και ως Chronic obstructive lung disease (COLD),
Chronic obstructive airway disease (COAD),
Chronic airflow limitation (CAL) and
Chronic obstructive respiratory disease (CORD)

_________________________________________________________________________________________________

RESEARCH ARTICLE

Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease:
A Meta-Analysis of Observational Studies

Abstract

Background

Many epidemiological studies have found a positive association between periodontal disease (PD) and risk of chronic obstructive pulmonary disease (COPD), but this association is varied and even contradictory among studies. We performed a meta-analysis to ascertain the relationship between PD and COPD.

Methods

PubMed and Embase database were searched up to January 10, 2012, for relevant observational studies on the association between PD and risk of COPD. Data from the studies selected were extracted and analyzed independently by two authors. The meta-analysis was performed using the Comprehensive Meta-Analysis software.

Results

Fourteen observational studies (one nested case-control, eight case-control, and five cross-sectional) involving 3,988 COPD patients were yielded. Based on random-effects meta-analysis, a significant association between PD and COPD was identified (odds ratio = 2.08, 95% confidence interval = 1.48–2.91; P<0.001), with sensitivity analysis showing that the result was robust. Subgroups analyses according to study design, ethnicity, assessment of PD/COPD, and adjusted/unadjusted odds ratios also revealed a significant association. Publication bias was detected.

Conclusions

Based on current evidence, PD is a significant and independent risk factor of COPD. However, whether a causal relationships exists remains unclear. Morever, we suggest performing randomized controlled trails to explore whether periodontal interventions are beneficial in regulating COPD pathogenesis and progression.

Copyright: © 2012 Zeng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

__________________________________

Read directly from the source

The article in pdf (for personal use)

Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease- A Meta-Analysis of Observational Studies

Σύνδεσμος στην Ελληνική γλώσσα

ΧΑΠ

__________________________________

Tracing Knowledge Notification | Ειδοποίηση Στα ίχνη της Γνώσης

UNMODIFIED COPY
of the original post, out of respect to the source (*) and readers.
Please follow the provided link for references and more informations.

(*) including scientists,artists,philosophers,writers,publishers,journalists and their entire work.

ΑΠΑΡΑΛΛΑΚΤΟ ΑΝΤΙΓΡΑΦΟ
της πρωτότυπης δημοσίευσης με σεβασμό στην πηγή και στους αναγνώστες.
Παρακαλώ επισκεφθείτε τον σύνδεσμο για περισσότερες πληροφορίες.

PLOS ONE: Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Observational Studies.

_________________________________________________________________________________________________

Zeng, X., Tu, M., Liu, D., Zheng, D., Zhang, J., & Leng, W. (2012).